Glazkov E. The role of intensive physical activity in formation of metabolic and immune body disorders and their correction by quercetin

The thesis is the complex research of the role of intensive physical activity in forming metabolic and immune disorders among professional swimmers while training. The research is also aimed to find out the way of rehabilitation on the basis of investigating immune and metabolic index. For getting high sport results athletes have to go through above-average and intensive training activity, that has a great effect on their bodies. The decrease of the level of body physical conditions, adaptation potential, the tension of adaptation mechanisms among the athletes with peak levels of intensity of physical activity were established. In groups with liminal and average levels of physical activity the index of cardiovascular system adaptation potential correspond the satisfactory adaptation level. It was determined that the evidence of immune and metabolic change depends on the level of physical activity intensity. The peak physical activity causes the suppression of neutrophils phagocytic activity, reduction of T- and B- lymphocytes content, progress of relative hypersupressor variant of postprimary immunodeficiency, inhibition of immunoglobulin synthesis. It was found out that from the point of metabolic homeostasis the extreme physical activity causes the activation of lipid peroxidation and enzymatic system of body antioxidant protection. The effectiveness of rehabilitation with "Quercetin granules" was proved. The usage of Quercetin bioflavonoid that has a massive immunomodulatory and antioxidant action promotes the decrease of immunodeficiency and lipid peroxidation, improving activity of enzymatic system of body antioxidant protection.