The investigation object: inflammation pathogenesis. The investigation goal: To define the role of opioid peptides in blood system reactions at inflammation. Methods of research: pathophysiological, cytomorphological,hematological, cytochemical, pharmacological, statistical. Theoretical and practical value of the obtained results: This work is a fundamental investigation. The obtained findings about the role of opioid peptides in inflammation pathogenesis expand the existing ideas about the mechanism of this process, which is important for development of general inflammation pathology and improvement of the methods of pathogenetic anti-inflammation therapy. The findings of the research demonstrated that in hyperergic acute inflammation m-opioids can be effective, while d– and k-agonists and m-receptor blockers are effective in chronic inflammation. The findings of the research can be used in further research work and teaching pathological physiology and other medical sciences. Scientific novelty of the obtained results: For the first time, special complex investigation of the role of endogenic opioid peptides in reactions of the blood system at inflammation (main effector system of this process) was performed. Anti-inflammatory modulating influence of opioid peptides on the reactions of different links of the blood system (leukocytes of inflammation focus, bone marrow cells, peripheral blood leukocytes) was determined. It consists of limitation of leukocyte accumulation (neutrophils, monocytes-macrophages, lymphocytes) in the focus of acute inflammation, their functional activity, hemopoiesis, karyocyte exit from the bone marrow to the blood. Receptor mechanisms of this influence associated with the significance of opioid k-, m- and d-receptors were shown. It was revealed that as to lymphocyte and monocyte reactions, opioid peptides act in one direction (increasing lymphocyte reaction and inhibiting monocyte reaction) via all three types of opioid receptors. As to neutrophil reaction, they work in different directions: via d- and k-receptors they increase it, while via m-receptors decrease it. In acute inflammation effect via m-receptors prevails. Stimulating influence of opioids on lymphocyte reaction, as well as this reaction itself, manifests at unusual course of inflammation. The degree of implementation: The findings of the research were introduced to the teaching process at departments of pathophysiology of Kharkiv and Donetsk National Medical Universities, Sumy State University, Ukrainian Medical Dental Academy and Crimean State Medical University.
