Tkachuk L. The diagnostic and prognostic value of the research on preplacental and innerplacental blood flow in the second trimester of pregnancy

The purpose of the given research was to decrease fetal pathology by means of improvement of diagnostic and prophylactic measures in the disorders of functional differentiation of fetal part of placenta. New data concerning peculiarities of sound conductivity of placental tissue during physiological and complicated course of gestational process were obtained in the result of conducted research. The increase of placental sound conductivity has been proved to be one of the indicators of functional differentiation of the placenta which is in the causal relation with the increase of the amount, density of location, and vascularization of stem fibers, with gestational transformation of internal placental hemodynamics. Main risk factors of the onset of retarded placental fetalization were sorted out. There was also defined diagnostic and prognostic value of the examination of exogenous placenta and blood flow in the umbilical artery when there are disorders of functional differentiation of fetal part of the placenta. It was suggested to score the placental fetalization based on the determination of placental tissue sound conductivity and indices of resistance of the umbilical artery. Screening examination of the condition of processes of functional differentiation of fetal part of the placenta was defined to be reasonably conducted during 28-30-week period of gestation. Placental fetalization disorders were proved to cause the progress of fetal distress. The use of Actovegin antihypoxant and Glutarginum nitrogen oxide donator was determined to be efficient during delayed functional differentiation of placenta. Techniques of help to pregnant women with placental fetalization disorders, that reduce progress frequency of fetal distress in 1.8 times, were developed, approved, and introduced into practice in obstetric institutions.