Rusalov V. Influence of bacterial peptidoglycans, teichoic acids and lipopolysaccharides on metabolic activity and apoptosis of neutrophils and subsets of T-cells in vitro

The thesis is devoted to the clearance of the influence in vitro of bacterial peptidoglycans, teichoic acids and lipopolysaccharides on metabolic activity and apoptosis of neutrophils and subsets of T-cells. It is shown that with the increase of teichoic acids, peptidoglycans and lipopolysaccharides concentration and time of their contact with neutrophils and T-cells' subsets the count of apoptic cells is increased, intracellular cyclic and adenylic nucleotides concentration is changed, lipid peroxidation is increased and the activity of antioxidant enzymes is decreased. The comparative analysis of neutrophils and T-cells' sensitivity to the action of teichoic acids, peptidoglycans and lipopolysaccharides is performed for the first time. It is established that T-helpers/inductors in comparison with neutrophils and cytotoxic T-suppressors are the most stable to the action of teichoic acids, peptidoglycans and lipopolysaccharides.