Oliper O. Clinical and morphological features of chronic hepatitis C in non-respondents and methods of its drug treatment

The thesis is dedicated to evaluation of clinical course peculiarities in HCV patients with genotype 1b who did not respond to antiviral therapy. Degree of antifibrotic changes in non-respondents has been defined and matrix-metalloprotainase-2 contents in patients' blood serum investigated. Antifibrotic effect of losartan which is an antagonist of angiotensin-ІІ receptor has been proved. It was determined that non-respondents had 1.3 times higher body weight index and high viral load in comparison with sick patients.Serious inflammation changes in liver and strongly marked fibrosis have been found in non-respondents who showed the signs of hemosiderosis of III-IV stages, which were revealed at histochemical investigation by Perls reaction.It was proved that valid MMP-2 increase in patients' blood serum who didn't respond to antiviral therapy depends on fibrosis level. The survey showed essential advantage of hepatoprotective and antifibrotic therapy in treatment of patients with high weight which led to substantial decrease of cholestasis and cytolysis indexes.