Belikova M. Adaptation of dopaminergyc nigrostrial, sympathoadrenal and antioxidant systems to intermittent hypoxia during aging and Parkinson disease

Candidate's dissertation in pathological physiology - 14.03.04. - A.A.Bogomolets Institute of Physiology National Academy of Sciences of Ukraine, Kiev, 2009. The dissertation focuses on studying of sympathoadrenal and antioxidant systems response to intermittent hypoxia during aging and dopamine insufficiency. There has been shown the asymmetry of dopamine distribution between right and left striatum of adult rats. Prevalent quantity of dopamine is concentrated in right hemisphere. Dopamine production in the striatum decreases during aging; at the same time its distribution asymmetry diminishes. Intermittent hypoxia training (IHT) increases dopamine synthesis, especially in the right striatum. IHT leads to decreased intensity of lipid peroxidation. At the same time it activates antioxidant systems. IHT decreases blood DOPA and increases blood noradrenaline concentration in healthy elderly people. In patients with Parkinson's disease (PD) it causes a decrease in blood DOPA and dopamine concentration and an increase in adrenaline and noradrenaline. Simultaneously the diminish of lipid peroxidation and activation of superoxid dismutase and catalase enzymes was observed both in healthy people and PD patients with L-DOPA treatment. In patients without L-DOPA treatment the catalase activity did not changed. It denotes the effectiveness of joint implementation of L-DOPA therapy with IHT.