Гунаева-Кручина О. Comparative characteristics of lipid lowering therapy effectiveness with atorvastatin in ischemic heart disease patients with and without coronary arteries surgical invasions

Thesis is dedicated to the research of the long term regular middle dose atorvastatin therapy influence on clinical and functional parameters, lipid specter, С - reactive protein and white blood cells level in patients with ischemic heart disease with and without reconstructive surgical invasions on coronary arteries to improve the efficiency of therapeutic approaches. It is found that long term regular middle dose atorvastatin therapy positively influences on clinical signs, functional parameters and life duration in ischemic heart disease patients. The frequency of endpoints difference in the groups of patients with and without surgical invasions on coronary arteries is statistically unreliable and does not depend on dyslipidemia type. Initially clinical condition of patients with and without surgical invasions on coronary arteries was not equal and it improved faster after the surgical therapy. At the same time the difference between initial levels and further changes of lipid specter during the long term stable middle dose atorvastatin therapy in patient groups are statistically unreliable. Lipid lowering effect is more fast and intensive in 2A type of dyslipidemia if compared to 2В type. Anti inflammatory effect of long term regular middle dose atorvastatin therapy in ischemic heart disease patients with and without surgical invasions on coronary arteries does not depend on dyslipidemia type, normalizing levels of С-reactive protein and white blood cells by the end of follow up period. Long term regular middle dose atorvastatin therapy in ischemic heart disease patients should be performed from the very beginning of disease diagnostics irrespective of dyslipidemia type and decision making regarding reconstructive surgical invasions on coronary arteries. Medications methods of therapy and myocardium revascularization procedures should not be opposed, but to add each other.