Kaberniuk A. Obtaining, modification and usage of diphtheria toxin recombinant subunits

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U000504

Thesis Registration Form

0410U000504.pdf

Applicant for

Specialization

  • 03.00.20 - Біотехнологія

22-02-2010

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Object: recombinant subunits of diphtheria toxin. Aim: obtaining and modification of recombinant subunits of diphtheria toxin and investigation of the practical application of recombinant proteins. Methods: molecular biology, immunological, biochemical, cell culture. The recombinant subunits of diphtheria toxin have been obtained as well as fluorescent derivatives of subunit B. The immunogenicity and antigen properties of recombinant subunits have been studied. The method of practical usage for detection of antibodies to different subunits of diphtheria toxin was proposed. Subunit B have been defined as protective antigen in the case of immunization animal susceptible to diphtheria toxin. Field of application: biomedical institutions.

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Files

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