Sekela T. Pathogenetic peculiarities of the course of severe injury combined with mechanical skin damage and xenodermoplastics

Dissertation is aimed at finding pathogenetic peculiarities of the course of severe injury combined with 10 percent mechanical skin damage and its correction by using xenodermoplastics. The model of severe injury has been worked out allowing to detect pathogenic mechanisms of extra mechanical removing of 10 percent of the skin surface as well as its course. The modeled severe injury is characterized by marked activation of the central outline of cardiac rhythm regulation and increased pulse blood filling of the animals’ body as well as decreased tonus of the arterial vessels. Besides, gradual decrease of the values of functional liver activity, increased activity of the marker cytolytic enzymes and lipid peroxidation, endogenic intoxication as well as the signs of exhaustion of antioxidant protection which get stable by the 7th day, are observed. Extra mechanical damage of 10 percent of the skin surface is accompanied by the marked impairment of the studied values, both dystrophic and necrotic changes in the liver, kidneys, heart and lungs, as well as by increased mortality of the experimental animals reaching 60 percent by the 7th day.The improvement of most studied values of variation pulsimetry, central hemodynamics, cytolysis, endogenous intoxication, lipid peroxidation, antioxidant protection as well as functional liver condition has been found at the background of xenodermoplastics. Less marked structural changes in the studied parenchymal organs have been found. No cases of mortality having been observed.