Mosula L. Synthesis and biological activity of thiazolidine derivatives with benzothiazole moiety in molecules

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U000834

Thesis Registration Form

0410U000834.pdf

Applicant for

Mosula Lyudmyla Markiyanivna

Specialization

15.00.02 - Фармацевтична хімія та фармакогнозія

Date of defense

19-03-2010

Specialized Academic Board

Д 35.600.02

Danylo Halytsky Lviv National Medical University

Essay

Object - reactions of [2+3]-cyclocondensation in synthesis of 4-thiazolidones, condensation reactions of 4-thiazolidine derivatives in methylene active group in position 5, reactions of acylation, alkylation and aminolysis; aim - synthesis of new thiazolidine derivatives with benzothiazole moiety in their molecules and search of effective and low-toxic agents with anticancer, antimycobacterial and antiviral activities among them; methods - traditional organic synthesis, mass-spectrometry, IR- and NMR-spectroscopies, X-ray analysis, elemental analysis, pharmacological screening, QSAR-analysis, docking; novelty - the effective new methods of synthesis and chemical modification for thiazolidine with benzothiazole moiety in molecules have been worked out, biological activity of synthesized compounds have been studied and "structure-activity" correlations have been carried out; the outcomes - the row of new perspective highly-active compounds, possessing antitumor, antimycobacterial and antiviral activities has been identified, recommendations for rational design of potential antitumor agents have been proposed based on obtaining data, docking and QSAR-analysis; these were introduced into scientific and educational process of National Pharmaceutical University, Zaporizzhia State Medical University, National University "Lviv Politechnic"; area - pharmacy.

Thesis supervisor

Lesyk Roman Bogdanovych

Official opponents

Новіков Володимир Павлович
Георгіянц Вікторія Акопівна

Files

aref_Mosula.doc

diser_Mosula--Tytulka.doc

diser_Mosula--Vstup.doc

diser_Mosula--Zagal'ni vysnovky.doc

diser_Mosula--Zmist.doc

diser_Mosula--dodatky--745159(3166)-1-OneDose.pdf

diser_Mosula--dodatky--745159(3166)-60-1.pdf

diser_Mosula--dodatky--745159(3166)-60-2.pdf

diser_Mosula--dodatky--745159(3166)-tox.pdf

diser_Mosula--dodatky--akty vprov_1.jpg

diser_Mosula--dodatky--akty vprov_2.jpg

diser_Mosula--dodatky--akty vprov_3.jpg

diser_Mosula--literature.doc

diser_Mosula--rozdil_1--liter_ogl.doc

diser_Mosula--rozdil_2--rozdil_2.doc

diser_Mosula--rozdil_2--tabl_2.1.doc

diser_Mosula--rozdil_2--tablycya-spectry-2.4.doc

diser_Mosula--rozdil_4--Table_4,3.doc

diser_Mosula--rozdl_3--rozdil_3new.doc

diser_Mosula--rozdl_3--table 3.2.doc

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