Kanana N. Mechanisms of myocardium remodeling under alloxan diabetes in rats with different sensitivity of АТ1 receptors

Object of investigation – diabetic cardiomyopathy, cardiac remodeling under diabetes mellitus, reactivity of organism; aim – to investigate mechanisms of myocardium remodeling in rats with different sensitivity of АТ1 receptors under alloxan diabetes; methods – physiological, biochemical, morphological, statistical; newness – it first shown that, reaction of АТ1 receptors sensitivity and intracellular signaling system activity during diabetes mellitus reflect peculiarities of reactivity of organism and determine a program of diabetic heart remodeling; long term hyposensitivity of АТ1 receptors at early stages of alloxan diabetes due to activation of eNOS-protein kinase G system and protein kinase А was accompanied with development of compensatory-adaptive processes; there is relation between АТ1 receptors sensitivity, degree of endothelial dysfunction and proinflammatory activation of monocytes-macrophages, rate of myocardium remodeling; development of early hypersensitivity of АТ1 receptors under diabetes mellitus is due to inhibition of eNOS and protein kinase А activity and can be accompanied with protein kinase C, phosphodiesterases and monocytic iNOS activity; it has established direct relation between dilation development, enhancement of ectopic electrical activity, decrease of heart ventriculi fibrillation level and degree of endothelial dysfunction, inflammation, cardiomyocytes hypotrophy, fibrosis; it has been introduced into medical practice and studying process; sphere - medicine.