Badiyin I. Study of mechanisms of Nitrites and Nitrates Low Doses Influence on Renal Function

Object - white rats (males) - intact animals and animals with experimental nephropathy induced by mercury dichloride; purpose - studying of effect of exogenous and endogenous nitrates and nitrites in small doses on normal renal function and damaged nephrons (e.g. with mercury dichloride); methods - pathophysiological, functional, biochemical, statistical and calculations; novelty – for the first time we found out that intact animals, under acute loading with 3% sodium chloride solution in volume 5% by body weight, increased system production and renal excretion of endogenous inorganic nitrogen oxides as compared to water loading; acute loading with 3% sodium chloride solution enhances renal excretion of exogenous nitrates and nitrites due to increased rate of glomerular filtration and decreased tubular reabsorption; after single administration to rats up to 2 mg per 100 g body weight of exogenous nitrites, no renal functional disorders were seen, but there was an adaptive response of nephrons on vascular-glomerular and tubular levels aimed in increased renal clearance of these substances; single administration to rats of sodium nitrate in amounts from 5 mg to 50 mg per 100 g body weight results in increased nitrites and nitrates plasma concentrations and their renal excretion; experimental renal insufficiency induced by mercury salts results in decreased system production and kidney excretion of endogenous inorganic nitrogen oxides against impaired renal capacity to increase rate of glomerular filtration at acute loading with 3% sodium chloride solution as compared to water loading; introduced - into medical practice, educational process; area - medicine.