Shpak I. Diastolic heart failure: etiological, clinical, morphological and functional features, the role of immune activation, the efficacy of treatment with angiotensin converting enzyme inhibitors during long observation

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U001279

Thesis Registration Form

0410U001279.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

26-01-2010

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The comparison of diastolic and systolic heart failure (HF) was performed. The signs of HF were less expressed at diastolic HF, among these patients there were women, arterial hypertension more often, and less often - coronary heart disease. We have revealed increased levels of serum concentrations of the tumor necrosis factor-alfa (TNF-alfa) and interleukin-6. Concentration of TNF-alfa depend on a functional class (FC) and diastolic dysfunction. The reception of сaptopril or enalapril at the diastolic HF reduced deterioration of FC, increase of requirement of diuretics, development of left ventricle dilatation, diastolic and systolic dysfunction. The application of these drugs in dozes 150 mg and 40 mg daily in the greater degree prevented left ventricle dilatation and diastolic dysfunction

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Files

AREF.doc

Диссертация.doc

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