Tugajbej I. Synthesis, physical, chemical and biological properties of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids derivatives

The paper deals with the search of new biologically active substances in the range of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids N-R-amides. The synthesis of N-R-amides of 2-hydroxy-4-oxo-4Н-pyrido[1,2-а]pyrimidine-3-carboxylic acids has been carried out and methods for their obtaining have been offered. To confirm the structure ultimate analysis, NMR spectroscopy, chromatomass-spectrometry, UV-spectrophotometry, as well as X-ray diffraction analysis have been applied. The diuretic and antiviral properties of substances synthesized have been studied. As the result peculiarities of the "structure - biological action" relationship have been determined and 2-diethylaminoethylamide of 2-hydroxy-9-methyl-4-oxo-4Н-pyrido[1,2-а]pyrimidine-3-carboxylic acid as a promising antiherpes agent can be recommended for further research.