Voloshyna O. Specific features of cell and humoral immune responses in patients having ischemic heart disease depending on coronary atherosclerosis prevalence and clinical manifestations of the disease

The thesis determines a relation of various types of cell and humoral immune response and intensity of coronary atherosclerosis, its clinical complications, and establishes a normalizing effect of statins on the cell and humoral immune state depending on the intensity of its disorders in patients having ischemic heart disease.It is demonstrated that 55 % of patients having stable angina show a hyperreactive type of immune response, associated with significant coronary atherosclerosis (damage of two and more coronary vessels). An autoimmune type of response in 30 % of patients having ischemic heart disease is combined with availability of such complications as myocardial infarction and left ventricle dysfunction. A suppressive type of cell immune response is not connected to the intensity of coronary atherosclerosis and its clinical complications, and is observed in 15 % of patients having chronic forms of ischemic heart disease.It is established that the immunoregulatory effect of Atorvastatin in a dose of 40 mg daily manifests itself in essential proved reduction of high levels of proinflammatory factors: SRP, IL-8, TNF?, CD40, IFN? in patients having a significant immunoinflammatory response and in moderate effect on inflammation factors at a low level of the immunoinflammatory process.It is established that Carvedilolum in a dose of 25-50 mg daily shows antioxidant properties, but has no effect on the blood lipid spectrum and the condition of the immune system in patients having stable angina.