Labenska I. Biological activity N-acyl derivates of S-(2-methylqunoline-4-yl)-L-cysteine

N-acyl derivates of S-(2-methylqunoline-4-yl)-L-cysteine. Search effective low-toxic hepatoprotectors in number of N-acyl derivatives and an establishment of dependence structure - biological action. Computer forecasting, chemical synthesis, the element analysis, thin layer chromatography, IR-, PMR-spectroscopy, chromato-mas-spectrometry, research of toxic action, antioxidative activity, hepatoprotective properties). It is settled that N-acyl derivates are considered as low-toxic and nontoxic compounds. Existence of antiradical activity of synthesized compound is settled. Basing on the model of toxic hepatitis it is settled that injection of N-acyl derivates (comparative compound - thiotriazolinum) protects cells membranes from hemolytic agents influence, increases hepatocytes membranes, metabolic processes and detoxicative function of the liver. Convenient method of synthesis of perspective hepatoprotector - di-Na-salt of N-succinoyl-S-(6-etoxi-2-methylqunoline-4-yl)-L-cysteine is worked out, deep research of its specific activity was conducted. On the base of voltamper curve changes it is settled that hepatoprotective activity is realized by means of antiradical and antioxidative properties. Sphere of use: bioorganic chemistry, мedicine.