Loai H. Infrared Absorption Analyzer in the Non-Invasive Means of the Blood Glucose Monitoring

In the thesis study methods and tools for the non-invasive analysis of glucose in human blood, new techniques of glucose measuring on the base of the surface tissue layers absorption spectra analyzing were investigated, new principles for development of accu-rate and safe means of the blood glucose measuring for people with diabetes were developed. The method of analysis of the tissue absorption spectra in the infrared range is developed, when the resonant properties of molecules of glucose and other blood components, including water, are sufficiently distinctive. Unlike to other methods for the glucose measurement based on the absorption spectrum the glucose to water ratio is determined in the same spectral range, which reduces errors and increases the range of measurements. A theoretical justification for the optimal absorption spectra filtering is executed. For glucose and water measurment the filters to suppress the influence of other blood components are designed. The computeraided algorithm for glucose concentration calculation is developed. A quasi color space is proposed for the glucose measurement results monitoring. Analysis of the infrared glucose absorption analyzer measuring channel was performed, a set of functional transformations is defined and the problems of practical im-plementation of optical, electronic and computer means for non-invasive glucose measurement are discussed. The simulation experiments are executed in which the optimal filters are designed to determine the concentration of glucose in a non-invasive way. The accuracy require-ments for the measuring channels to achieve the required accuracy of glucose concentration measurement are determined. Using the experimental system of the non-invasive glucose measurement the infrared absorption analyzer testing was performed which showed the high performance of the proposed methods and algorithms for the non-invasive glucose concentration meas-urement.