Kononenko O. The role of asymmetric dimethylarginine in formation and progressing of chronic renal disease in children

The study is devoted to problem of nonimmune mechanisms of developing and progressing of chronic renal disease in children with the help of investigation of ADMA in plasma and structural and functional connections between the level of arginine and nitric oxide; markers of lipid, protein, immune turnover, hemodynamic data. It was proved that in children with easy signs of kidney disease and their normal function, the level of ADMA in plasma was significantly increased that shows the easy signs of endothelial dysfunction. The severe increase of ADMA level in plasma, delay of nitric oxide synthesis (according to the level of stability of metabolites of nitrates and nitrites) in children with signs of kidney insufficiency shows disorders of processes of vasodilatation/vasoconstriction and leads to vasoconstriction. The main reason of chronic renal disease developing are: disorders of arginine turnover and nitric oxide turnover; dysfunction of cell and humoral links of immunity. The main factors which determine the progressing of chronic renal disease is the kidney dysfunction (decrease of glomerular filtration rate level, urine density, disorder of nitrogen excretion function); progressing of anaemia and increase of ADMA level in plasma. It shows that disorders of arginine turnover and nitric oxide turnover take equal part in the process of developing of chronic renal disease. The concentration of ADMA in plasma has the prognostic meaning and value which allows the use this sign in complex system of chronic renal disease prognosing. Key words: children, asymmetric dimethylarginine, nitric oxide, chronic renal disease, renal and central hemodynamic, endothelial dysfunction.