Sirman V. Influence of an embryo’s progenitor cells of the rat on pathophysiologic mechanisms of kidneys at Peerson’s adjuvant arthritis (experimental research)

The thesis is devoted to the theoretical generalization and substantiation of an embryo’s progenitor cells transplantation on the basis of pathological mechanisms of kidneys damage under experimental arthritis. It has been shown that modeling at rats Peerson’s experimental arthritis is followed by complex progressing damage of renal function. In two months from the beginning of arthritis development they could find clear signs of excretory (decrease of diuresis, increase of proteinuria with occurrence of hypercreatinemia) and ion-regulating renal function (increase of natrium excretion and further development of hyponatriemeia). For the renal function damages are responsible: increase of anti-inflammatory cytokines, activation of lipid peroxidation and proteolysis of tissues. Biochemical and function damages revealed progress and achieve their maximum in 12 months of observation and combine with morphological signs of a damage. Intravenous infusion to the rats of embryonal progenitor cells at the amount of 3,5x 107/ml per a kg of a body mass in three weeks of arthritis modeling was followed by a promoted protective action as to the part of kidneys. From 2 to 12 months of experiment are largely restored the functional state of kidneys.