Shai D. Antiviral activity and interferon productivity of low-molecular inducers of interferon - analogs of amixin and derivative diphenyl

The candidate degree thesis is devoted to interferon productivity and antiviral activity of a fundamentally-new interferon's inducers - analogs of amixin and derivatives of diphenyl in vitro and in vivo. In vitro, in L929 cell culture revealed that the studied compounds have interferon productivity abilities in doses no higher than those for which the effective Amixin (4-31 ?g / ml). Demonstrate that the antiviral activity of the investigated compounds caused by their interferon-inducers action in vitro to determine the relationship between the planar structure and biological effects of newly-synthesized compounds. For research in O.V. Bogatsky Physico-Chemical institute NAS of Ukraine was synthesized by a number of compounds, which differed from the prototype (amixin) as the replacement of side chains and changes in the planarity The author has detected the studied compounds in vivo increases the pool of interferon response of cells more intensely than officinal product - Amixin. Determine the ability of new interferon inducers to increase rates of cytokine animals infected with herpes simplex virus. The using of these compounds showed that compounds № 9, № 10 and loramixin are more active antiviral agents compared with аmixin in experimental herpetic infection: the magnitude of the multiplicity of security compound № 9 reaches 100,0; loramixin do not differ from that of the comparison drug (10.0). Investigated polycyclic compounds have several advantages over officinal product Amixin that allows us to consider them as promising inducers of interferon and antiviral drugs.