Buchko O. Diabetus mellitus tupe 2 impact on the cell and humoral immunity and immunocompetent blood cell structure in patients with coronary heart disease

Object - type 2 diabetes in patients with unstable angina.Purpose - improve diagnosis and treatment of unstable angina, its combination with diabetes mellitus type 2 based on the study of cellular and humoral immunity and ultrastructural changes of immunocompetent blood cells in these patients. Methods - clinical, laboratory, instrumental, statistical. Novelty - he influence of the first type 2 diabetes on ultrastructural features and immunological changes of immunocompetent blood cells in patients with PSD, it is proved that the severity and duration of type 2 diabetes in patients with directly affects not only the changes in cellular and humoral immunity, but on immunocompetent blood cells, according to electron microscopic studies, has been shown that type 2 diabetes in patients with NA promotes apoptosis of lymphocytes, monocytes, monocyte-macrophages and neutrophil leukocytes, a correlation between the immunological parameters of apoptosis in lymphocytes (CD95+) and programmed death of other immunocompetent blood cells according to ultrastructural studies in patients with NA in combination with type 2 diabetes. Results - to determine the expediency of the immune system in patients with NA in combination with type 2 diabetes to predict the severity of these diseases, evaluation of expression of immunological parameters will predict both the severity of the clinical course of type 2 diabetes and the likelihood of development of the contingent of CHD patients who be taken into account during the treatment and secondary prevention; expediency cytoprotector application in complex therapy of type 2 diabetes and the NA to prevent apoptosis of immune cells blood introduced into the practice of medical institutions, scientific and educational process. Industry - Medicine.7452