Novorodovska T. Impact of structure-dependent organellar and non-organellar calcium binding on intracellular signalization: model study

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U000068

Thesis Registration Form

0411U000068.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

14-12-2010

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

Studies of Ca2+ dynamics in dendrites of model neurons containing buffers and stores (endoplasmic reticulum or mitochondria), showed that Ca2+ signals in the cytosol are determined by the ratio of membrane area to organelle-free volume of a dendritic segment, and in organelle store – by its membrane area. Rates of reaction of binding to transport molecules of the stores determine the kinetic characteristics of Ca2+ storing and are limited by saturation of the transport system. Ca2+ dynamics is influenced directly by the local microgeometry, and indirectly by the global geometry and asymmetry of branching dendrites.

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Files

aref.doc

dis.doc

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