Shumova I. Pathogenesis of long-term proton-pump inhibitor administration influence on periodontium tissues and its correction

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U000911

Thesis Registration Form

0411U000911.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

25-03-2011

Specialized Academic Board

Д29.600.02

Essay

Dissertation work is aimed at a study of pathogenesis development in periodontium tissues at long-term proton pump inhibitor omeprazole administration and the basis of experimental correction of these changes by multiprobiotic of last generation "Symbiter". It is proved that the leading role in the development of pathological changes in periodontium tissues at the long-term omeprazole-induced hypoacidity play: disbalance of NO-ergic system, activation of oxidative stress, development of endogenic intoxication, decompensation of proteinase-inhibitor potential, increase collagenolytic activity, activation of depolymerization of collagen fibers, proteoglycans and glycoproteids.

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