Gargat E. Functional, metabolic and cytological disturbances in human blood neutrophils and monocytes under the influence of bacterial endotoxins and method of their correction in vitro

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U001149

Thesis Registration Form

0411U001149.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

24-12-2010

Specialized Academic Board

Д29.600.02

Essay

The thesis is devoted to the clearance of the influence in vitro of bacterial endotoxins on functional, metabolic and cytological status in human blood neutrophils and monocytes, and to the developing of the method of their correction with dalargine application. It is shown that bacterial endotoxins at their contact in vitro with neutrophils and monocytes inhibit their phagocytosis, stimulate secretion of mediators, activate lipid peroxidation processes, decrease the activity of antioxidant enzymes, modulate the balance between intracellular cyclic nucleotides and also intensify apoptosis. It is shown that preliminary treatment with dalargine of neutrophils and monocytes that in future have the contact with endotoxins significantly decreases apoptogenic, immunosuppressive and dismetabolic action of endotoxins.

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Files

aref.doc

dis.doc

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