Kubashko A. Condition of pro- and antioxidant equilibrium in the Chornobyl catastrophe victims (remote postaccident period)

On the ground prostective and retrospective investigation the described features of changes of oxidizing homoeostasis in liquidators of consequences after accident Chornobyl NPP 1986-1988 in different postaccident period during 1992-2009, that are connected with the severity of radiation injury and dose of irradiation. The signs of homoeostatic, protein-modifying, membrane-destabilizing effects are revealed, and misbalance of levels of paramagnetic metalloproteins of blood is fixed in the examined persons in a remote period after an irradiation (2006-2009). It is shown that with the increase of the radiation loading there is a decline of the functional backup of AO-protection and disturbance of functioning of paramagnetic metalloproteins on a background of activating of protein-modifying effects, that can be ponderable factors in worsening of pathological condition in this category of victims in the remote postaccident terms. It is investigated, that with the increase of the postaccident period (from 1992 to 2009) in liquidators of consequences after accident on Chornobyl NPP irradiated in dose >0,25 Gy it is observed the reliable decline of the general functional state of АО-system on the level of integral factor of antioxidant defend (FAOD) on a background of strengthening of disproportional output of primary and intermediate products of lipoperoxidation, accumulation of lipid and protein derivates with carbonyl groups, switching over of AO-protection to glutathioneperoxidase; in dose >1,00 Gy - reduction of level of erythrocytic glutathione, and in dose >2,00 Gy - activity of Zn/CuSОD of red blood cells, disorder of cross-correlation connections between Zn/CuSОD and Е-CAT, at decrease their activity did not connected with influence of the age, that is sign of oxidative homeostasis systems individualized radiosensibility. The received results can be used in the medical practice with the purpose of optimization of clinico-diagnostic and therapeutic approaches in treatment of persons with chronic diseases, which are associated with enhance of free-radical oxidization.