Bruzycka O. Determination of the indexes of endogenous intoxication and state of micro circulation in patients with exudates and toxic erythemas

Object of research - toxicoderma during the acute illness. Research objective - to improve the treatment effectiveness of patients with exudative multiforme and toxic erythema by studying the features of the development and formation mechanisms of endotoxemia and the use of reasonable pathogenetic therapy. Methods: clinical, toxicological, immunological, tools, statistics. Clinical displays, etiologic factors, seasonal dependence, state of micro circulation, immunological indexes, are studied. Approach of the systems is first carried out to the study of mechanisms of forming of endotoxicosys and toxin-induction of autoimmune reactions depending on the clinical displays of toxic dermatitis. That the initial period of motion of toxic dermatitis is accompanied development of toxemia the level of which answers a heavy degree (after laboratory gradation). Features which depend on the clinical forms of toxic dermatitis have displays of toxins. Cross-correlation copulas are first conducted between endotoxicosys and by immunological indexes, found out reliable cross-correlation dependence between them. It is developed diagnostic and treatment program, which allowed on the early stage a disease - leadthrough selective directed and the nosotropic grounded therapy, to more rapid complete regression of clinical picture from 30,7 days to 21,5 days, that shortened duration of treatment and proof remission is attained during time of inspection. Results have been implemented in the practice of the Kiev city Venereal Diseases Hospital, regional dermatovenerologic dispensary № 4, National Children's Specialized Hospital "OKHMATDYT". Use area - dermatovenerology.