Gorbulenko N. Isoflavonoids Modificated by N-Containing Heterocycles. Synthesis and Properties

The thesis is dedicated to the synthesis of new (un) substituted 3-azahetarylchromones, products of their modification and transformation and systematic investigation of chemical and biological properties of synthesized compounds. The modifications of 3-azahetarylchromones was realized by acylation, alkylation, aminoacylation of hydroxy groups of 7-hydroxy-3-azahetarylchromones. The investigation of 3-azahetarylchromones with nucleophilic and electrophilic reagents were carried out and series of pyrazole, pyrimidine, isoxazole and 2-amino-3-azahetarylchromone derivatives and Mannich bases were obtained. The introduction of formyl function in series of 3-azahetarylchromones were realized. The modification of 8-formyl-3-azahetarylchromones with 2-azahetarylacetonitriles led to condenced system with azaheterocyclic nucleus both in chromone and а-pyrone fragments. The new approach to synthesis of 3-(2-quinoline)chromanones was offered. N-containing heterocycles and chromone rings are often found in molecules playing an important role in biochemistry as well as in many drug molecules. Being in the same molecule they represent a useful source of exploratory chemistry for the discovery of novel physiologically active compounds. Hypolipidemic, anabolic, analeptic, cytoprotective, hepatoprotective, hypoglycemic activities of some synthesized 3-azahetarylchromones were established by means of pharmacological screening.