Pankratiev O. Alkilselenonaphthyridine effect on morphofunctional adaptation of a brain to a chloroformic intoxication

The investigation object: a brain at a chloroformic intoxication without АСНР and during its administration. The investigation goal: to specify influence АСНР on rising of resistance of an organism and activization of morfofunctional mechanisms of adaptation of a brain to a chloroformic intoxication. Methods of research: modelling of a chloroformic intoxication without АСНР and during its administration; definition of activity of a catalase in blood serum and in a brain homogenate; definition of permeability of a blood-brain barrier and level of the general water in a brain of experimental animals; brain research at histological and elektronno-microscopic levels; statistical researches. Theoretical and practical value of the obtained results: the modified mean of experimental modelling of a chloroformic intoxication at rats is offered. The design procedure of daily dose АСНР for laboratory animals is specified. Indicators of activity of a catalase in blood serum and in a brain homogenate, level of the general water and permeability of a blood-brain barrier at intact and investigated animals are calculated. This data can be used in the further researches. It is defined histological and elektronno-microscopic characteristics of a cortex of the big cerebral hemispheres during development of a chloroformic intoxication without АСНР and during its administration. Scientific novelty of the obtained results:For the first time in experiment it is in a complex studied influence of АСНР on rising of resistance of an organism and activization of mechanisms of adaptation of the brain to a chloroformic intoxication. Are resulted morfofunctional brain characteristics at a chloroformic intoxication without АСНР and during its administration. For the first time it is established that introduction of АСНР positively influences on morfofunctional brain adaptation at a chloroformic intoxication: activity of a catalase in blood serum and a homogenate of the brain decreased, that specified in rising of antioxidatic protection at the expense of АСНР. Level of the general water and permeability of a blood-brain barrier are decreased. At histological and elektronno-microscopic levels reduction of a venous plethora and signs of an edema-swelling of a brain is established. The degree of implementation: a research specification introduced into educational process of chairs of laboratory diagnostics, biological chemistry and anatomy, human physiology and animals of Lugansk national university of a name of Taras Shevchenko; chairs of pathological physiology and operative surgery with topographical anatomy of the Crimean state medical university of S.I.Georgievsky (Simferopol); chairs of medical biological chemistry of Lugansk state medical university. 2 efficiency proposals are introduced.