Kozhanova T. Cytokines homeostasis alterations and their correction effects on cardiac structural and functional parameters in patients with arterial hypertension

Thesis for the Degree of Candidate of Medical Sciences on specialty 14.01.11 - Cardiology. Interrelationship of cytokines profile (serum levels of transforming growth factor beta1, interleukine-1beta, interleukine-4 and tumor necrosis factor alfa) with cardiac remodeling clinical manifestations of chronic heart failure (CHF) in patients with arterial hypertension (AH) and influence of lipoflavon on the above named parameters have been studied. The total of 116 AH patients, including 89 hypertensive subjects with cardiac remodeling and CHF and 27 hypertensive subjects without cardiac remodeling and CHF were enrolled. Control group included 20 subjects without AH, CHF, cardiac remodeling, clinical and laboratory signs of inflammation. Has been shown that increased levels of active transforming growth factor beta1 are present in majority of AH patients with cardiac remodeling. Increase of transforming growth factor beta1 concentration is associated with higher degrees of hypertrophy and diastolic dysfunction of left ventricle, higher functional class of CHF. Beside that increased activity of transforming growth factor beta1 was accompanied by additional elevation of serum interleukine-1beta, interleukine-4 and tumor necrosis factor alfa. In vitro study revealed that lipoflavon inhibited interleukine-1beta and tumor necrosis factor alfa production by peripheral blood mononuclear cells of AH patients with cardiac remodeling. Also has been shown that adding of lipoflavon to conventional therapy of AH patients with cardiac remodeling and CHF is safe and causes improvement left ventricular diastolic function and CHF functional class.