Sharashydze K. Immunological shifts in the organism of pregnant women with intrauterine growth retardation and their complex therapy.

The research deals with an urgent problem of modern obstetrics: an increase in the efficacy of treatment of intrauterine growth retardation (IUGR) in pregnant women by means of specification of immunological peculiarities in pathogenesis and development of a complex therapeutic technique, which uses СН. The thesis is based on sufficient clinical material (120 pregnant women, 90 of them having IUGR). In the process of the research modern clinical, sonographic, doppler, immunological and statistical methods of examination were used. For the first time, this work revealed the part of immunological disturbances in the development of the above pathology on the basis of a combined clinical-laboratory examination of pregnant women with IUGR. For the first time, interdependence of immunological changes in pregnant women with IUGR and the foetal state by the data of instrumental studies was scientifically proved. For the first time, it is recommended to use CH for treating IUGR as a multicomponent drug, which produces a positive effect on immunological shifts taking place in the organism during pregnancy with growth retardation. The normalizing influence of СН on the state of cellular immunity, cytokine status and protein-synthetizing function of the placenta was revealed. The effect of CH on the state of the pregnant woman and foetus was studied, its high efficacy for treating IUGR and absence of any complications after its use were proved. The author suggests pathogenetically grounded therapeutic measures and her algorithm for managing pregnancy and labour in women with IUGR, which make it possible to prevent development of complications in the mother and foetus in such cases.