Zenko N. Features of the violation and correction of calcium metabolism in craniocerebral trauma occurring on the background glucocorticoid osteoporosis

The investigation object: craniocerebral trauma, shok, calcium metabolism, steroid osteoporosis, in rats. Their osteoporosis of three degrees of severity has been modeled. The investigation goal: 1. To develop an experimental model of a severe craniocerebral trauma in the background of steroid osteoporosis in the experiment. 2. To study peculiarities of calcium metabolism in steroid osteoporosis of three degrees of severity in the experiment. 3.To study peculiarities of calcium metabolism in a CCT of three degrees of severity in the experiment. 4.To study peculiarities of the pathogenesis of a CCT in the background of osteoporosis of three degrees of severity, to determine the typical characteristics of calcium metabolism disturbances and an individual reactivity in dynamics of a posttraumatic reaction. 5. To ground the application of calcitonin and to value its medicinal efficacy in a CCT in the background of steroid osteoporosis in the experiment. Methods of research: pathophysiologic, physiologic, X – ray methods; biochemical, statistic methods. Theoretical and practical value of the obtained results. Scientific novelty of the obtained results: For the first time pathogenesis and metabolic disturbances of calcium homeostasis in animals with a craniocerebral trauma and osteoporosis will be made more precise. Application of calcitonin will be grounded, its medicinal efficacy in a CCT will be determined. The role of parathyroid hormone and calcitonin in these disturbances will be established. A limiting link of pathogenesis for exogenic administration of a therapeutic form of calcitonin – miacalcic will be determined. The degree of implementation: Donetsk Regional Clinic Of Traumatology and orthopedic, Science Institute Of Traumatology and orthopedic, M. Gorky Donetsk National Medical University, Institute of Urgent and recovery Surgeon National Medical Science academy, Pedagogical process on Pathophysiological departments Donetsk and Lugansk Medical Universities