Nagorichna I. 1,3-Dihydrooxazino-, furo-, spiropiranocoumarins and 6-hetarylcoumarins, synthesis and properties

The replaced coumarins and their derivatives. Synthesis and development of optimum approaches to designing of the new derivative coumarins which contains elements of a structure peculiar for natural compounds - free hydroxyl and acyl groups, annelational pyranes and furanes heterocycles, farmacological heterocycles (a pyrazol, a pyrimidine, an indole); development of methods of their synthesis, studying of the further ways of their chemical modification; research of physical and chemical properties and reactionary ability, and also search among them bioregulators of various action. Organic synthesis, spectroscopy methods (IR, UV and a NMR), the element analysis, and the thin-layer chromatography, pharmacological screening. The row of the modified analogues of natural furocoumarin, psoralen, was synthesized; the row of derivatives which contain the fragment of natural alkaloid, cytyzine, was synthesized; the reactions of C-aminomethylation were conducted; 3-substituted 5,7-dihydroxy-4-methycoumarins were synthesized and their antioxidant properties were explored. The row of spiroanalogues of natural pyranocoumarin, graveolon, was obtained using cyclic ketones in the Kabbe condensation. Geterocyclization of enamino-ketones with hydrazine and guanidine was first applied to the synthesis of 6-pirazolyl- and pirimidinylcoumarins. The new coumarins systems which contain indole cycle were obtained as a result of condensation of 6-acetylcoumarins with N-phenylhydrazine in the conditions of the Fisher reaction. Scope of application - bioorganic chemistry.