Grekova T. The State of Pancreatic Islets Endocrinocytes in Experimental Animals with Different Etiology and Pathogenesis Hyperglucemia

The thesis is devoted to the study of morphological and functional state of pancreatic islets endocrinocytes in aging normal rat and in rats with hyperglycemia, caused by various pathogenic factors. It has been established the features of morphological and functional condition of pancreatic alpha-, beta-, delta-cells and cells, that synthesize amylin, in hyperglycemia development in normal Wistar rat and rat with experimental diabetes mellitus, experimental gestational diabetes and arterial hypertension (SHR). It has been shown that morphological and functional parameters changes and time of their occurrence depend on certain pathogenic factor actions. For the first time it was investigated the changes of amylinsynthesizing cells' morphological and functional parameters in different etiology and pathogenesis hyperglucemia. It has been shown the ability not only beta-cells to synthesize amylin, but other cells of pancreatic islet. The practical importance of this work is the possibility to create methods of preventing the development and progression of carbohydrate metabolism disorders in old age, when it is established adverse effect of exogenous factors, as well as in the initial stages of aretrial hypertension.