Al H. Clinical-metabolic and immunologic peculiarities in patients with discirculative encephalopathy that felt under the influence of ionizing radiation due to the accident on ChAES

The object of examination - patients with discirculative encephalopathy that felt under the influence of ionizing radiation due to the accident on ChAES, purpose - improvement of diagnostic methods and clarification of mechanisms of development discirculative encephalopathy in patients that felt under the influence of ionizing radiation due to the accident on ChAES, on the basis of studying clinical-metabolic and immunologic indexes for optimization of treating programmes, methods - general clinical, double x-ray absorptiometry, immunologic, biochemical, statistical, mathematical; novelty - for first time people, who lives in Ternopil region and felt under the influence of ionizing radiation due to the accident on ChAES in a remote period after (more than 20 years) were examine clinical-diagnostic peculiarities of discirculative encephalopathy by using clinical-neurologic, immunological and biochemical characteristics, for first were study peculiarities of changes in bone tissue and dependence of these indexes on the concomitant pathology, age of the patients, stage and variant of the disease, the dose of radiation based on analyses of bone-mineral tissue condition due to double x-ray densitometriy results, got further development in researches of endogenous intoxication syndrome and concentration of Nitrit-anion in patients with discirculative encephalopathy that felt under the influence of ionizing radiation due to the accident on ChAES; for the first time was set connection between clinical-neurologic signs of discirculative encephalopathy, stage of bone tissue changes, level of lipoperoxydation changes, concentration of Nitrit-anion, immunologic changes and degree of endogenous intoxication syndrome; results - was diagnosed decreased concentration of Nitrit-anion, development of endogenous intoxication syndrome, suppressed T-cellular part of immunological protection on the background of enlargement of some components of humoral immunity in these patients; was studied peculiarities of bone mineral density in patients with discirculative encephalopathy; was established dependence of these indexes on the age of the patients, stage and variant of the disease, and the dose of radiation; was proved necessity of optimization of treating programmes due to the changes of metabolic and immunologic indexes.