Voiteshenko I. Physical factors of 2'-deoxyribopolynucleotides helicity: quantum-mechanical modeling

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U004579

Thesis Registration Form

0411U004579.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

20-09-2011

Specialized Academic Board

Д 26. 001. 08

Essay

The aim of the presented thesis is to establish the main physical factors, responsible for the spiral structure of 2'-deoxyribopolynucleotides, especially DNA, by low-molecular models of sugar-phosphate backbone in different charge forms and using modern quantum-chemical methods. All obtained conformers are analyzed for their basic energy and geometric characteristics. Some structures allowing of forming biologically important DNA forms sugar-phosphate backbone are selected from the set of obtained conformers. Some specific intramolecular interactions, which stabilize the spatial structure of biologically important conformers are identified.

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Files

Voiteshenko_disertation.pdf

aref_Voiteshenko.doc

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