Gordiichuk O. Neurological deficit, gait disorders and mental dysfunction dynamics in patients with multiple sclerosis.

Thesis is dedicated to studying the dynamics of neurological deficits, cognitive dysfunction and disorders of gait in patients with multiple sclerosis in srednedlitelnoy term follow-up (1 - 3), as well as the effect on the progression of deficit drugs that modify the course of the disease (beta-interferons, Copaxone). We examined 249 patients with stages of multiple sclerosis outpatients (male 86 (34.54%) and women - 163 (65.46%).Used the following methods: evaluation stage of the disease and the structure of neurological disorders by the method of EDSS, functional disorders - the procedure MSFC, Isaacs test, assessment of quality of life by the method of EQ-5D, an MRI study of brain function and instrumental study on how to walk GAITRite ®. In the dynamics of 1, 2 and 3 years, established the presence of three patterns of changes in the medium term - an improvement (up to 30 - 40% of patients in each period), and stable over the deterioration (whether or not clinically established exacerbations).Opposite changes of the patients studied in different fields have different values and generally had a very modest connection with each other.