Object of the study - unstable angina (UA). Purpose - to increase the effectiveness of diagnostics and treatment of UA based on the study of connective tissue (CT) metabolism, lipid metabolism, immunological reactivity and adjuvant therapy with usage of metabolic agent lipoflavon. Methods - clinical, laboratory, instrumental and statistical. It was proved that the course of UA is accompanied by changes in metabolism of CT - the disintegration of the collagen dominate over its synthesis. It was found that changes in anabolism of CT in patients with UA have heterogeneous nature. In most patients, a significant reduction of TGF-B1 was found, but in a small number of patients TGF-B1 stays in the normal range or exceeds the acceptable norm. These patients oftenshow increased levels of oxyroline in urine. It was shown that slow anabolic processes are associated with obesity, increased - with a high degree of hypertension, smoking and age over 65 years. In case of slowing down of anabolic processes in CT angina pectoris attacks develop on the basis of psychoemotional loads, errors in diet, accompanied by elevated blood pressure. In patients with reduced anabolic processes in CT marked increase in the number of CD3 +, CD4 +, CD16 +, CD19 +, CIC, IgM, and IRI is registered. In patients with UA disorders of lipid metabolism are associated with the slowdown of anabolic processes in CT. Results: in 61.1% of patients TGF-B1 is significantly reduced, in 10% within normal range, in 28.9% - higher than normal. In patients with normal valuesof TGF-B1 the level of oxyproline in urine exceeds 1.5 times; deceleration of anabolic processes is associated with obesity, increased - with a high degree of hypertension, smoking and age over 65, in patients with predominantly catabolic processes atypical symptoms of angina are frequently observed. They are prone to more frequent complications such as heart rhythm disorders and conduction disorders, show anomalous chord in ventricular chambers and aneurysm of the ascending aorta. In decelerating of anabolic processes angina attacks are provoked by psychoemotional loads and errors in diet, in 76.9% of patients with enhanced anabolic processes - increased blood pressure, development of unstable angina in patients with CHD is associated with the activation of T-cell immunity with simultaneous strengthening of the humoral response; course of unstable angina is accompanied by proatherogenic changes of blood lipid spectrum. Dyslipidemic changes are seen together with low TGF-B1, a complex treatment of unstable angina using lipoflavon performs better than baseline. Application of lipoflavon faster and to a greater extent eliminates angina attacks, reduce the need in nitrates. The results are introduced into the practice of therapeutic establishments, educational and methodical process. Industry - medicine.
