Lukyanova A. Characteristics of the spectrum of primary and additional cytogenetic rearrangements on different stages of chronic myeloid leukemia

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U005438

Thesis Registration Form

0411U005438.pdf

Applicant for

Specialization

  • 14.01.31 - Гематологія та трансфузіологія

30-06-2011

Specialized Academic Board

Д 26.612.01

State Institution "Institute of Hematology and Transfusiology NAMS Ukraine"

Essay

The PhD dissertation presents results of the study investigating the incidence, spectrum, diagnostic and prognostic significance of different types of primary cytogenetic rearrangement and additional chromosomal abnormalities in chronic myeloid leukemia. The different ways of chimeric BCR/ABL gene formation such as typical or complex translocation and submicroscopic insertions are shown. There was created an algorithm for cytogenetic and molecular cytogenetic diagnostics of chronic myeloid leukemia. Identification of additional cytogenetic changes occurrence in Ph-positive cells during therapy is a sign of disease progression.

Read more

Files

aref.doc

dis.doc

dis.doc

Similar theses

0421U101048

Kozlova Olena Igorivna

Optimization of diagnostics and treatment in childhood non-Hodgkin lymphoma

0421U101049

Tymoshenko Uliana V.

Diagnostic significance of molecular biological factors of immune hemolysis of B-cell non-Hodgkin lymphoma

0420U102464

Borysenko Yevheniia Alexandrovna

Clinical and laboratory features of intoxication syndrome in patients with acute leukemia

0420U102463

Korzh Andrii Volodymyrovych

Comparative characteristics of biochemical parameters of donor blood plasma collected through different methods

0520U100499

Dmytrenko Iryna V.

The role of genetic abnormalities in the development of resistance to tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia