Tkachova V. Ethoxymethylidene derivatives of CH-acids in the reactions with C-nucleophiles: synthesis of functionalized pyridines, pyrimidines and their transformations.

The object of research - 3-arylcarbamoylpyrid-6-ones, 3-cyanopyrid-6-ones, heterocyclization. The objective of research - the preparative methods for the synthesis of new series of 3-arylcarbamoylpyrid-6-ones and 3-cyanopyrid-6-ones developed by the reaction of nucleophilic vinylic substitution using ethoxymethylidene derivatives of CH-acids and different cyanoacetanilides or their acyclic analogs. Method of investigation and equipments - experiment, physico-chemical and spectral characteristic of compounds (1H and 13C NMR spectra, IR spectra, mass spectrometric, X-ray Structure determination, TLC). Theoretical and practical results - the different pathways of the reactions depended on the nature of reagents and reaction conditions were studied. Intermediates of SNVin reaction, and side reaction products or by-products were also isolated. The obtained products were used for the synthesis of new alkylsulfanylpyridines. The antioxidant properties and antimicrobial activity of some substances were studied. Novelty - the systematically studied the possibility of synthesis of 3-cyanopyrid-6-оnes from ethoxycarbonyl, arylcarbamoil or cyano groups in fifth position, 3-arylcarbamoilpyrid-6-ones, 2-sylfonilpyridines and 4,7-di(alkylthio)pyrido-[2,3-d]-pyrimidine-6-carbonitriles. Efficiency of application - adoption is in plan. Sphere (field) of using - dissertation results can be use in the work of chair of chemistry and biochemistry State establishment "Luhansk Taras Shevchenko National University".