Chernukhina O. Influence of precursors and blockers of nitric oxide synthesis on pathogenesis of liver and kidney damage in diabetes mellitus (experimental investigation)

Dissertation is dedicated to the studying of peculiarities of liver and kidney status under the influence of precursors and blockers of nitric oxide synthesis in streptozotocine diabetes mellitus. NO precursor L-arginine-L-glutamate increases NO synthesis with concomitant decrease of hyperglycemia, attenuates biochemical and morphological signs of liver and kidney damage in diabetic rats. Inhibitors of NO synthesis N-nitro-L-arginine, more so aminoguanidine, contribute to the acceleration of the biochemical and histological changes in diabetes. Combined administration of L-arginine-L-glutamate and aminoguanidine for hepato- and nephropathy in diabetes mellitus is less beneficial as compared with single administration of L-arginine-L-glutamate. The fact confirms the importance of proper NO synthesis in realization of hepato- and nephroprotective activity of L-arginine-L-glutamate in diabetes.