Іegorova A. Influence of arterial blood pressure hypertensive type orthostatic reactions on the currency and effectiveness of arterial hypertension treatment.

Thesis is dedicated to the research influence of arterial blood pressure hypertensive type orthostatic reactions on the currency and effectiveness of arterial hypertension treatment in different types of therapy. Frequency distribution of arterial blood pressure hypertensive type orthostatic reactions were identified in healthy persons of young and old age and also in arterial hypertension patients. Also age peculiarities of arterial blood pressure hypertensive orthostatic reactions distribution were identified. With age frequency of arterial blood pressure hypertensive type orthostatic reactions decreases. Gender differences in frequency of systolic and diastolic arterial blood pressure orthostatic reactions in healthy are absent and not connected with age. In female patients with arterial hypertension the hypertensive type orthostatic reactions prevail both for systolic and diastolic arterial blood pressure. It was identified that the frequencies of systolic blood pressure hypertensive orthostatic reactions reduced on 27%, 29% and 13% correspondingly in calcium antagonist, ?-adrenoblocker and angiotensin converting enzyme inhibitors therapy groups. Frequency of diastolic blood pressure hypertensive orthostatic reactions reduced on 20%, 34% and 32% correspondingly in calcium antagonist, ?-adrenoblocker and angiotensin converting enzyme inhibitors. . It was discovered that the quality of life indexes has increased in all groups and sub-groups, mainly due to the index of health increase. At the same time in a sub-group with hypertensive orthostatic reaction the quality of life index exceeded the level of quality of life index in the isotensive reaction sub-group. All medications increased the quality of life indexes, angiotensin converting enzyme inhibitors in a greater extent, calcium antagonist in a less extent and ?-adrenoblocker in the least measure, disregarding of patients sub-group. At the same time in the hypertensive orthostatic reaction of arterial blood pressure sub-group the extent of these indexes increase was lower than in than in patients with isotensive reaction disregarding therapy. The most favourable for the arterial hypertension current were non-qualified hypertensive orthostatic reactions of systolic and diastolic blood pressure, in which the frequency of death, stroke and myocardial infarctions was less than in isotensive and qualified hypertensive orthostatic reactions of systolic and diastolic blood pressure. More favourable current of arterial hypertension was seen in the group of angiotensin converting enzyme inhibitors, intermediate - calcium antagonist, and less favourable - ?-adrenoblocker. It was identified that in the therapy of arterial hypertension it is necessary to control the systolic and diastolic blood pressure orthostatic reactions of in such way that they were kept in the range of non-qualified hypertensive orthostatic reactions of systolic and diastolic blood pressure.