Lukavetskyy N. Prognostic factors in surgery of esophageal and gastric cardia cancer

Dissertation is dedicated to the study of the detection of prognostic factors in esophageal and gastric cancer surgery. The median survival rate of patients without TGF-B and CD44 expression was significantly lower than that of patients with positive expression. However elderly patients have statistically significant better survival (median 20,2 month) compared with younger patients (median 15,4 month) radical surgery can be performed at acceptable risk in elderly patients. Patients with second primary esophageal or gastric cancers have significant worse survival compared with routine primary upper digestive tract cancer. Extended gastrectomy with thoracotomy is the better choice of surgical treatment of gastric cardia cancer compared with standart abdominal gastrectomy. In case locally advanced gastric cardia cancer there are high rate of lymph dissemination into thoracic cavity. Selective mediastinal lymphadenectomy should be considered for locally advanced gastric cardia tumours.