Rudnyeva I. Clinical characteristics of cardiovascular system in young patients with diabetes mellitus type 1 and approaches in management of its dysfunctions

Thesis is devoted to improvement of diagnostics cardiovascular and vegetative complications of children with diabetes mellitus type 1 and elaboration of medical correction. It was showed that diabetic cardiomyopathy has been found in 48,46% of patients with diabetes mellitus type 1. It was determined that frequency of cardiomyopathy depends on duration of diabetes. Analysis of the Heart rate variability identified that children with diabetes mellitus type 1 had a combined parasympathetic and sympathetic dysfunction. It was covered that human insulin analogues combination of glargin and glulisin has more optimal influence on the variability of heart rate. It was proved that diabetic patients have the left ventricular hypertrophy with elaboration of following types of left ventricular remodeling as concentric remodeling, concentric hypertrophy, eccentric hypertrophy. It was revealed that level of NTproBNP was variable and depends on duration of disease. Increased level of NTproBNP occurred in patients with duration of diabetes more than 5 years and can be used as a criteria of preclinical diagnostics of the diabetic cardiomyopathy. In complex treatment of early symptoms of the diabetic cardiomyopathy in children with diabetes metabolic drug meldonium dehydrate has been recommended.