Sarzhevskaya A. The metabolic disorder role of homocysteine in endothelial dysfunction evolution in middle and old aged patients with angina pectoris

The object of study - stable angina - FC II-III inmiddle and old aged patients; goal - setting features metabolism of homocysteine, the functional state of the vascular endothelium, autonomic nervous system, myocardial ischemic changes, quality of life in this age group of patients with angina, the possibility of therapeutic correction of changes with an ACE inhibitor, perindopril, methods - clinical, biochemical, immunnofermental, instrumentation, medical, social, statistical, novelty - found correlation of homocysteine metabolism with the state of the vascular endothelium, the quality of life, the expression of molecules sICAM-1, shows the possibility of using perindopril in the complex therapy of angina in middle and old aged patients, introduced into the practice of Zaporozhye Regional Clinical Hospital, Zaporozhye Regional Hospital for disabled World War, Central Hospital Ordzhonikidze district (Zaporozhye), City Clinical Hospital № 2, № 6 (Zaporozhye), the Regional Hospital for disabled World War (Dnepropetrovsk), in the pedagogical process of Zaporozhye State Medical University, Zaporzhskoy Medical Academy of Postgraduate Education, Dnepropetrovsk State Medical Academy.