Object for investigation: opportunistics microorganisms, suppurative inflammatory-purulent complications of lymphoblastic leukemia. The aim: to make with microbiological investigation a ground for elaboration and use of antiseptics for treatment and prevention of microbial complication at lymphoblastic leukemia. Methods of investigations: microbiological, physical-and-chemical, statistical. Equipment: microscope "Biolam", thermostat (incubator), autoclave, hot air oven, pH meter, camera "Olympus". At first time antimicrobial ability of antiseptic solutions, such as horosten, decasan, miramistin, septefril, stomatidin, has been investigated for clinically actual and valuable strains which circulate in the oral cavity of patients with lymphoblastic leukemia. New data about spectrum and specifity of officinal antimicrobial medicines using at different level of pH, protein concentration and microbial loading have been noted in research. The degree of influence of horosten, decasan, miramistin, and septefril onto adhesive property of microorganisms which caused inflammatory complications within patients with lymphoblastic leukemia has been detected. The rapidity of antiseptic resistance formation has been revealed for clinical isolates as well as reference strains. Microbial resistance formation has been studied to horosten, decasan, miramistin, septefril, stomatidin. It has been proved decametoxin and cephalosporin antibiotics (cefotaxime, ceftriaxone ) demonstrate potential antimicrobial effect on each other. Obtained research results demonstrate advantages of horosten, decasan, and septefril use for prevention and therapy of infectious complications in oral cavity of patients with lymphoblastic leukemia. The level of introduction: The results have been added to Analytic normative documents about substance of medical antiseptic decamethoxine registed in State Register of medicines of MHU Ukraine (registrative card №П. 10.02/05401 , 9th October, 2009), рill antiseptic septefril (registrative card № UA/7930/01/01, 13th March, 2008); antiseptic medicine horosten (registrative card № UA/2048/01/01, 17th July, 2009); medicine decasan (registrative card № UA/5364/01/01, 23rd July, 2007). The results have been incorporated to study course of high education medical school departments such as microbiology, virology and immunology; pediatrics department; dental pathology and children's infectious diseases. Branch of usage: medicine (stomatology, pediatrics, children's infectious diseases).
