Garas M. Severe persistent bronchial asthma in children of school age (diagnostic criteria and treatment).

Object of study: bronchial asthma in children. The aim of the study. Optimize the control of asthma in school-age children through the application the once-daily regime of supplementation with basic therapy with an average degree of severity of disease. Methods: clinical, immunological, cytological, allergological, instrumental, biochemical, sociological, statistical. Resultes: On the basic of complex examination of 122 children of school age who suffer from severe and moderate persistent bronchial asthma there have determined specific features of a severe form of taking into account atopy markers, indeces of nonspecific reactivity of the bronchi on histamine inhalation and physical strain, character of inflammation in the respiratory tract as well as immunological blood indeces and markers of bronchial inflammation in expiratory air condensate. On this ground there has been established the diagnostic value and risk indeces of the the studies made for verification of severe bronchial asthma in relation to a moderate gravity of the disease. The results of multifunctional correlating analysis being the ground, there has been worked out a mathematical model for gravity of bronchial asthma and a constellatory diagnostic table for verification of severe and moderate bronchial asthma. To raise the efficacy of controlled therapy grounded on the gravity, there has been created an algorithm of diagnosis for severe and moderate bronchial asthma in children of school age on the basis of indeces of their paraclinical examination.