Shuprovich A. Peculiarities of uric acid metabolism disorders in type 2 diabetic patients (clinical and experimental study)

Subject of the study: insulin resistance (IR) syndrome, type 2 diabetes mellitus (DM). Objective of the study: to analise gender peculiarities of uric acid (UA) metabolism disorders in aged type 2 diabetes patients and their interrelations with insulin resistance (IR), obesity, iron overload, insulin and testosterone levels. Methods of the study and devises: clinical, biochemical, antropometric, radioimmunological, statistical; spectrophotometer СФ-46, analizer "Humolyser 2000", counter "Gamma 5500". Theoretical and practical results: peculiarities of uric acid (UA) metabolism disorders in type 2 diabetes in men and women and their interrelations with insulin resistance (IR), obesity, iron overload, insulin and testosterone levels is determined. High frequency of uric acid metabolism disorders in aged diabetic patients was revealed, which manifested as hyperexcretory normouricemia (HNU) or hyperuricemia (HU), and their mechanisms differ dependently from gender, rate of obesity, insulin and testosterone level. Assessment of UA metabolism and practical recomendations for diagnostic of type of UA metabolism disorders can be additional criterion of hormonal and metabolic characterisation in therapy of aged type 2 diabetic patients. Novelty: for the first time 2 symptomocomplexes in type 2 diabetic patients were characterized, and peculiarities of their formation were established in dependence from gender, IR, obesity, iron overload, insulin and testosterone levels. Implementation stage: the results of study are used in clinical practice of department of clinical pharmacology and age endocrinology of State institution "V. P. Komissarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Science". Application area: endocrinology, diabetology.