Simagina T. Effects of lipid-lowering therapy on cardiovascular system morphological and functional features in the patients with coronary artery disease before and after coronary artery bypass graft surgery combined with aneurismectomy

Thesis is dedicated to the study of peculiarities of medication therapy in prevention of postoperative cardiac arrhythmias, improvement of the immediate and long-term effects of of coronary arteries bypass graft surgery combined with aneurismectomy in the patients with CAD and postinfarction cardiosclerosis by adding mandatory preoperative lipid-lowering medications. The thesis is based on complex prospective examination of 234 patients with CAD and PIC before and after CABG+AE, of which did not receive statins before surgery, followed-up for 18 months after surgery. Groups of comparison were comparable by age and gender. It was shown that administration of statins lipid-lowering therapy after CABG+AE leads to significant reduction of ocurrence of cardiac arrhythmias, IMC thinning, lipids panel indices improvement, as well as HRV indices positive dynamics. Also, lipid-lowering therapy potentiates myocardial function restoration after surgery according to EchoCG exam. Factors affecting incidence of end points (cardiovascular death, worsening heart failure) in the patients after CABG+AE were studied.