Tishchenko O. Clinical and pathogenic approach to the rehabilitation of women with the history of missed abortion.

This work first studied the features of microcenesis in the endometrium and cervical canal in women with the history of missed abortion, developed a new complex of modern methods of investigation, both the endometrium and immune system changes in local and hormonal status, the proposed rehabilitation of reproductive function in patients with the history of missed abortion. The study involved 124 women, including 64 women with diagnosed missed abortion, (main group). The comparison group 30 women with physiological pregnancy who were performed artificial abortion. The control were 30 healthy women in pregravidae period. The clinical and anamnestic, histological and immunological features of the endometrium and its functional activity were investigated. Pathogenetic mechanisms of menstrual dysfunction were defined in women with the history of missed abortion. The changes in the secretory transformation of the endometrium, a sharp decrease in its receptor and functional activity, confirming the lack of development of the luteal phase. Based on the research, developed and implemented in practice an algorithm for the restoration of menstrual function in women in the postgravidae period, using PCE. The data confirmed the feasibility of implementing the proposed examination and treatment of women with the history of missed abortion.