Gunkova V. Clinical and immunological basis of pathogenetic therapy of impetigo

Object of research - impetigo. Research objective - improvment the efficiency of impetigo treatment by developing the method of complex pathogenetic therapy on the basis of study of regulatory molecules indicators that influence the migration of leukocytes, pro- and antiinflammatory effects of immune response. Research methods: general clinical laboratory, special (nitroblue tetrazolium test, radial immunodiffusion, enzyme immunoassay method), statistical. The thesis is devoted to improve the diagnostic and treatment of patients with chronic recurrent impetigo vulgaris on bases of the study the role of system molecular intercellular ratio. It was observed 120 patients and 20 apperently healthy persons. Functional disability of neutrophils, molecules which are responsible of adhesion (ICAM-1) and chemotaxis (IL-8), antiinflammatory cytokines (IL-10), disorder of cellular and humoral immunity were established. The complex treatment using Rybomunil and "Miltrium with beta carotene" provides absence of recurrence or state improvement in 90% patients, the renewal of the pre-physiological indicators of changed system molecular intercellular ratio. Results have been implemented in the practice of Zaporizhzhya Regional and the Donetsk city of clinical dermatovenerological dispensaries, dermatovenereological department of Romny central regional hospital of Sumy region, and also in the pedagogical process of departments: professional diseases and radiation medicine of Donetsk National Medical University named after M. Gorky, skin and venereal diseases of Dnipropetrovsk State Medical Academy. Use area - dermatovenerology.